Notification of addition to or amendment of charge.

1. by way of legal mortgage, all the freehold and leasehold property now vested in or charged to the company including:. All that freehold land adjoining harrow house, county trading estate, transport way, oxford OX4 6LX registered under title no. ON260244.. All that freehold land and buildings lying to the north east side of watlington road, cowley registered under title no. ON80837.. All that freehold land situated at unit 1, chancerygate business centre oxford, transport way, cowley, oxford OX4 6HE registered under title no. ON271362.. 2. by way of fixed charge all estates or interests in any freehold and leasehold property now and in the future vested in or charged to the company except the property charged by the preceding clause.

1 wuindrush court transport way oxford titel no ON79849 ON164954 patent wo 98/17817-trin vectors-rev/rre (obm 6) (UK patent application nr.990413.6. Please see image for details of further land (including buildings), ship, aircraft or intellectual property charged.

Unit 5 mead road yarnton oxford t/no on 316087.

(A) first legal mortgage over 1 windrush court and harrow house, transport way, oxford, OX4 6LT (title no. ON79849, ON164954, ON80837, ON260244, ON271362) and all other real property owned by oxford biomedica (UK) limited; (b) first fixed charge over all other real property owned by oxford biomedica (UK) limited; and (c) first fixed charge over patent wo 01/79518 codon optimized gag/pol (obm 47) (with ep no. 1278878 and 2194137) and all other intellectual property owned by oxford biomedica (UK) limited. For more details of assets charged, please refer to the instrument.

The mortgaged properties being: property name: windrush court, transport way, oxford, OX4 6LT; title no: ON79849 and the other mortgaged. Properties as specified in schedule 1 to the instrument.